| Q | heating rate |
| Q | pitch rate |
| Q&A | question and answer |
| Q-alpha | pitch dynamic pressure |
| Q-beta | yaw dynamic pressure |
| QA | quality assurance |
| QA | quality audit |
| QA&T | quality assurance and test |
| QAC | quality assurance chart |
| QACAD | QA corrective action document |
| QAD | Quality Assurance Division (MSFC) |
| QAFM | QA Forms Manual |
| QAM | QA Manual |
| QAOP | QA operating procedure |
| QAP | QA procedure |
| QAP | quality assurance product |
| QAR | quality assurance report |
| QAVT | qualification acceptance vibration test |
| QC | quality control |
| QCB | queue control block |
| QCDR | QC deficiency report |
| QCM | quartz crystal microbalance |
| QCOP | QC operating procedure |
| QCS | qualified calibration source |
| QD | quick disconnect |
| QDR | qualification design review |
| QDS | quality data system |
| QE | quadrant elevation |
| QE | quality engineer |
| QE | quality engineering |
| QEC | quick engine change |
| QEL | queue element |
| QFD | quality function deployment |
| QFD | quality functional deployment |
| QGS | quantity gauging system |
| QI | quality information |
| QIC | quality information control |
| QL | quick look |
| QLDS | quick-look data station |
| QLS | quick-look station |
| QM | qualification motor |
| QMS | qualification model spacecraft |
| QPD | quality planning document |
| QPL | qualified parts list |
| QPL | qualified products list |
| QPP | quality program plan |
| QPR | quarterly progress report |
| QPRD | quality planning requirements document |
| QPRD | quality program requirements document |
| QPRH | Quality Planning Requirements Handbook |
| QPS | quantity planning specification |
| QPSD | Quality and Productivity Systems Division |
| QPSK | quadrature phase shift key |
| QQPRI | qualitative, quantitative personnel requirements |
| QRE | quick-reaction estimate |
| QRI | quick-reaction integration |
| QRIA | quick-reaction integration activity |
| QRS | qualification review sheet |
| QRS | quartz rate sensor |
| QRS | quick-reaction sortie |
| QRSL | quick-reaction space laboratory |
| QSA | qualification site approval |
| QSGVT | quarter-scale ground vibration test |
| QSIM | queuing simulation |
| QSL | qualified source list |
| QSM | quarter-scale model |
| QSS | quindar scanning system |
| QT | qualification test |
| QTP | qualification test plan |
| QTP | qualification test procedure |
| QTR | qualification test report |
| QTV | qualification test vehicle |
| QUADS | quality achievement data system |
| QUAL | Quality Assurance Division (MSFC) |
| QUES | queueing model for message dissemination |
| QUI | Quito, Ecuador (STDN) |
| QUIC | quality data information and control |
| QUIC | quality information control |
| QUP | quality unit pack |
| QVT | qualified verification testing |
| QVVT | qualified verification vibration testing |
| q | dynamic pressure |